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-- fr | en the inmg teams bessereau genetics and neurobiology of c. elegans boulin molecular and cellular neurobiology of c. elegans castellani neuro-development, cancer, and signaling chazaud stem cell environment and skeletal muscle homeostasis courchet energy metabolism and neuronal development durand cilia assembly and development gache muscle nuclear and cytoskeletal architecture gieseler muscle biology and pathogenesis giglia-mari dna excision repair at the crossroad with transcription honnorat synaptopathies and autoantibodies (synatac) jacquemond excitability and ca 2+ signaling in normal and diseased skeletal muscle lomonte chromatin assembly, nuclear domains, virus marcelle muscle formation, growth and repair schaeffer nerve-muscle interactions news & highlights publications 2016-17-18 students yrin - young researchers of inmg job offers seminars intranet reservations institut neuromyogène cnrs umr 5310 - inserm u1217 - université de lyon - université claude bernard lyon 1 search we have moved! after two years of construction, the 200 members of the neuromyogène institute moved in late december 2017 into the beautifully renovated premises of the rockefeller school of medicine lyon-est. this operation is part of the ambitious renovation project of the rockefeller building built in 1929 by paul bellemain, student of tony garnier, and made possible by the support of the auvergne rhône-alpes region, the métropole de lyon, the contrat plan etat région and university claude bernard lyon 1. the 14 research teams of the institute occupy 3,500 m 2 of lab and office space on the third floor of the building. they benefit from state-of-the-art technical platforms for imaging, physiology and genomics. a 500 m 2 extension of the laboratory will be completed at the end of 2018, and will allow a first wave of recruitment for new teams. aging cell unc-120/srf independently controls muscle aging and lifespan in caenorhabditis elegans. mergoud dit lamarche a, molin l, pierson l, mariol mc, bessereau jl, gieseler k, solari f in this study, mergoud et al. identify unc-120/srf as the first conserved transcription factor that regulates the pace of muscle aging in a cell autonomous manner, downstream of the insulin/igf1 receptor. more information about the science of jean-louis bessereau's team stem cell reports coupling between myogenesis and angiogenesis during skeletal muscle regeneration is stimulated by restorative macrophages latroche c, weiss-gayet m, muller l, gitiaux c, leblanc p, liot s, ben-larbi s, abou-khalil r, verger n, bardot p, magnan m, chrétien f, mounier r, germain s, chazaud b. in this study, chazaud et al., evidenced that endothelial cells (ecs) and myogenic progenitor cells (mpcs) interacted to couple myogenesis and angiogenesis during skeletal muscle regeneration. ec- and mpc-derived apelin, oncostatin-m and periostin controlled myogenesis/angiogenesis coupling and were required for myogenesis and vessel formation. moreover, we showed that via the production of oncostatin-m, restorative macrophages promoted myogenesis/angiogenesis coupling. more information about the science of bénédicte chazaud cnrs press release (french) cancer cell microenvironment-driven shift of a cohesion/scattering balance within tumors induces a switch towards metastasis in neuroblastoma delloye-bourgeois c, bertin l, thoinet k, jarrosson l, kindbeiter k, buffet t, tauszig-delamasure s, bozon m, marabelle a, combaret v, bergeron c, derrington e, castellani v the castellani team developed an aggressive human neuroblastoma (nb) model based on the graft of nb cells at their primitive environment, the neural crest, in avian embryos. this model recapitulates both the primary tumor formation and nb cells secondary dissemination and allowed identifying two major routes of dissemination: peripheral nerves and aorta. the team described a microenvironment-induced pro-metastatic process, regulated by a cohesion signaling controlled by sema3c via nrp/plxn complexes. more information about the science of valérie castellani's team embo journal ampkα1-ldh pathway regulates muscle stem cell self-renewal by controlling metabolic homeostasis marine theret, linda gsaier, bethany schaffer, gaëtan juban, sabrina ben larbi, michèle weiss-gayet, laurent bultot, collodet caterina, marc foretz, dominique desplanches, pascual sanz, zizhao zang, lin yang, guillaume vial, benoit viollet, kei sakamoto, anne brunet, bénédicte chazaud & rémi mounier theret et al. identify ldh as a new functional target of ampkα1 in muscs, where it is a direct regulator by which the oxidative phosphorylation/aerobic glycolysis balance can be shifted to control differentiation/self-renewal. more information about the science of rémi mounier and bénédicte chazaud's team molecular psychiatry a critical role for vegf and vegfr2 in nmda receptor synaptic function and fear-related behavior. de rossi p, harde e, dupuis jp, martin l, chounlamountri n, bardin m, watrin c, benetollo c, pernet-gallay k, luhmann hj, honnorat j, malleret g, groc l, acker-palmer a, salin pa, meissirel c. increasing evidence indicate that the vascular endothelial growth factor (vegf) can facilitate memory performances but its impact on synapses remains poorly understood. de rossi et al. now show that vegf exerts a direct effect on synapse structure and function through its receptor vegfr2 on neurons. this vegf-vegfr2 pathway is required for hippocampal synaptic plasticity and consolidation of memory. more information about the science of jérôme honnorat's team pubmed -- immunity cnrs press release science & santé nature reviews immunology macrophage ppar gamma , a lipid activated transcription factor controls the growth factor gdf3 and skeletal muscle regeneration. tamas varga, rémi mounier, andreas patsalos, péter gogolák, matthew peloquin, attila horvath, attila pap, bence daniel, gergely nagy, eva pintye, szilárd poliska, sylvain cuvellier, sabrina ben larbi, brian e. sansbury, matthew spite, chester w. brown, bénédicte chazaud, laszlo nagy pparγ is a lipid activated transcription factor essential for fat cells and linked to lipid processing in macrophages. varga et al. (2016) now show that pparγ is transcriptionally active and regulates the growth factor gdf3 in repair macrophages in regenerating skeletal muscle, forming a paracrine axis connecting macrophages to muscle progenitor fusion. more information about the science of bénédicte chazaud's team -- research teams inmg houses 14 research teams focusing on the physiology of the neuromuscular system, cellular and molecular neurobiology and nuclear dynamics. more news & highlights jean-louis bessereau's team has launched the project "c.napse" with the support of a prestigious erc advanced grant (erc adg 2015) from the european research council. the group of jean-louis bessereau is investigating the molecular organization of chemical synapses, which are the specialized structures supporting communication between neurons in the brain and between neurons and muscles at neuromuscular junctions. more publications 2016-17 seminars friday 29 june laure strochlic institut de myologie, paris regulation of neuromuscular connectivity by wnt signaling from signaling molecules to therapeutic strategies thursday 31 may robert j. johnston johns hopkins university, baltimore stochastic gene expression and nuclear architecture in fly eyes and human retinal organoids wednesday may 17th 14:00 – salle guillermond - bât. l’herbier hélène castel normandie rouen university / inserm 1239 – team astrocyte and vascular niche. cancer and cancer treatments on cognition: a major translational impact of the preclinical research -- more job offers team chazaud two post-doc positions in skeletal muscle stem cell environment [2018-01-08] profile 1 – exploration of the role of extracellular matrix in skeletal
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